A MICROFLUIDIC PLATFORM FOR SIMULTANEOUS QUANTIFICATION OF OXYGEN-DEPENDENT VISCOSITY AND SHEAR THINNING IN SICKLE CELL BLOOD

A microfluidic platform for simultaneous quantification of oxygen-dependent viscosity and shear thinning in sickle cell blood

The pathology of sickle cell disease begins with the polymerization of intracellular hemoglobin under low oxygen tension, which leads to increased blood effective viscosity and vaso-occlusion.However, Long Sleeve Polo it has remained unclear how single-cell changes propagate up to the scale of bulk blood effective viscosity.Here, we use a custom mi

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Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma

BCL2, BCL6 and MYC are major oncogenes in B-cell lymphoma.Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to BCL2 and MYC or fuse diverse partner genes with BCL6.So-called double-hit lymphomas usually carry BCL2 and Shape Sorter MYC rearrangements, while tripl

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Molecular Characterization of White Wines Antioxidant Metabolome by Ultra High Performance Liquid Chromatography High-Resolution Mass Spectrometry

The knowledge about the molecular fraction contributing to white wines oxidative stability is still poorly understood.However, the role of S- and N-containing compounds, like glutathione and other peptides, as a source of reductant in many oxidation reactions, and acting against heavy metals toxicity, or lipid and polyphenol oxidation as ROS-scaven

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In-depth analysis of the expression and functions of signal transducers and activators of transcription in human ovarian cancer

BackgroundSignal transducers and activators of transcription (STAT) transcription factors, a family of genes encoding transcription factors, have been linked to the development of numerous types of tumors.However, there is a relative paucity of a comprehensive investigation of the expression and functional analysis of STATs in ovarian cancer (OV).M

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